Upcoming Seminars

Causal Inference in Drug Development: Why, When, How?

a BBS / BES Seminar

Date and time:

  • 21 August, 2019
  • 08:30 – 16:00

Venue:

  • F. Hoffmann – La Roche
  • Roche Building 001 (Tower)
  • Auditorium 2nd Floor
  • Grenzacherstrasse 124
  • 4070 Basel, Switzerland

 

  •  Registration:
  • Free of Charge; Please note that you only register for the Seminar. The 2-days course has to be registered via email.
  • Registration is closed for this event
Agenda 

08:30 – 9:00 Registration

09:00 – 9:10 Welcome from the organizing committee

9:10-10:40 Causal Inference in Drug Development – Why or why not

(Session chair: N.N.)

What you need to know (Miguel Hernan, Harvard)

Relation to ICH E9 (Christine Fletcher, Amgen)

A regulator’s perspective (Frank Pétavy, EMA)

10:40 – 11:10 Coffee break

11:10 – 12:30 Case studies 1 (Session chair: Giusi Moffa, University of Basel) Adverse reactions confounded by prior medication: (how) can causal inference solve the problem? (Valentine Jehl, Novartis)

Treatment sequencing and effectiveness: challenges and considerations (Thibaut Sanglier, Roche)

12:30 – 13:20 Lunch

13:20 – 14:40 Case studies 2 (Session chair: N.N.)

Principal stratification techniques in the context of regulatory decision making (Nikolaos Sfikas, Novartis)

Estimating treatment effects in the pharmaceutical arena using instrumental variable methods: from “academic” causal inference to the Estimand Framework via the CANTOS study (Jack Bowden, University of Bristol)

14:40 – 15:00 Coffee break

15:00 – 16:00 Panel discussion: Where do we go from here?

Session chairs: Sigrid Behr, Novartis and N.N. Including all Speakers

16:00 Closure of the meeting