Upcoming Seminars

Causal Inference in Drug Development: Why, When, How?

a BBS / BES Seminar

Date and time:

  • 21 August, 2019
  • 08:30 – 16:00

Venue:

  • F. Hoffmann – La Roche
  • Roche Building 001 (Tower)
  • Auditorium 2nd Floor
  • Grenzacherstrasse 124
  • 4070 Basel, Switzerland

 

  •  Registration:
  • Free of Charge; Please note that you only register for the Seminar. The 2-days course has to be registered via email.
  • Registration is closed for this event
Agenda 

08:30 – 9:00 Registration

09:00 – 9:10 Welcome from the organizing committee

9:10-10:40 Causal Inference in Drug Development – Why or why not

(Session chair: N.N.)

What you need to know (Miguel Hernan, Harvard)

Relation to ICH E9 (Christine Fletcher, Amgen)

A regulator’s perspective (Frank Pétavy, EMA)

10:40 – 11:10 Coffee break

11:10 – 12:30 Case studies 1 (Session chair: Giusi Moffa, University of Basel) Adverse reactions confounded by prior medication: (how) can causal inference solve the problem? (Valentine Jehl, Novartis)

Treatment sequencing and effectiveness: challenges and considerations (Thibaut Sanglier, Roche)

12:30 – 13:20 Lunch

13:20 – 14:40 Case studies 2 (Session chair: N.N.)

Principal stratification techniques in the context of regulatory decision making (Nikolaos Sfikas, Novartis)

Estimating treatment effects in the pharmaceutical arena using instrumental variable methods: from “academic” causal inference to the Estimand Framework via the CANTOS study (Jack Bowden, University of Bristol)

14:40 – 15:00 Coffee break

15:00 – 16:00 Panel discussion: Where do we go from here?

Session chairs: Sigrid Behr, Novartis and N.N. Including all Speakers

16:00 Closure of the meeting

 

Downloads

Seminar: “Missing data – What can we do?”

Download Presentation: Christian Schindler                                                           BES 2018 Christian Schindler_Overview of statistical methods

Download Presentation: Audrey Muller                                                                     BES 2018 Audrey Muller_Comparative effectiveness in rare disease

Download Presentation: Gracy Crane                                                                          BES 2018 Gracy Crane_Comparative effectiveness of patients

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Seminar: “Challenges when studying associations between exposure and outcomes with long latencies”

Download Presentation: Prof. Dr. Christoph R. Meier BES_Benzos_Dementia_Meier_23.06.2017

Download Presentation: Anna Beckmeyer-Borówko, PhD, MBA BES_Beckmeyer_Borowko_Population_based_studies

Download Presentation: S. Behr & D. Rosenberg                           BES_Assessing-long-term-latencies-for-newly-marketed-drugs

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Seminar: “Propensity Score Methods for Causal Inference? “

Download Presentation: Julia Spoendlin

BES-2018-Introduction to Propensity Score Methods_Julia Spoendlin_17.08.2018

Download Presentation: Giusi Moffa, PhD

BES-2018-Causal Inference DAGs_Giusi_Moffa

Download Presentation: Alexander Michel, MD MSc

BES-2018-Alexander Michel- Propensity Scores

Download Presentation: Sigrid Behr

BES_Sigrid Behr _For-causal-inference-rare-outcomes

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Seminar: “Patient Preferences – methods and relevance for medicinal decision making”

Download Presentation: Conny Berlin

1_BES_BBS Seminar 22Nov2018_Introduction PP_CBerlin

Download Presentation: Stuart Osborne

2_BBS_BES Seminar 22Nov2018_PrefMab_RochePDMABiometrics_StuartOsborne_22Nov2018Final

Download Presentation: Evan Davies 

3_BBS_BES Seminar 22Nov2018_Evan Davies

Download Presentation: Florian Gutzwiller

4_BBS_BES Seminar 22Nov2018_FGutzwiller_GMCC

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Satellite Seminar on Causal Inference

Download Part 1 Introduction to Causal Inference and directed acyclic graphs EMD:

BES 5_July_2019 part 1 Introduction to Causal Inference and directed acyclic graphs EMD

Download Part 2 DAG to identify covariates to adjust for confounding Final GDP:

BES 5_July_2019 part 2 DAG to identify covariates to adjust for confounding Final GDP

Download BES 5_July_2019 part 2  sim_data GDP: (.XLSX)

BES 5_July_2019 part 2 sim_data GDP